A Case of Pediatric Spitz Melanoma With a ZEB2 :: ALK Fusion

Key Points

• This report investigates a rare case of Spitz melanoma in a child with an ALK fusion to evaluate treatment responses.
• A 3-year-old male patient presented with Spitz melanoma and ZEB2::ALK fusion.
• Initial treatment involved wide local excision and neoadjuvant immunotherapy with a PD-1 inhibitor.
• Patient underwent surgical resection followed by adjuvant radiation therapy and targeted therapy with lorlatinib.
• The tumor was aggressive and showed recurrence after initial excision.
• Immunotherapy failed to control the progression of the melanoma.
• Adjuvant targeted therapy with lorlatinib was initiated to address the ALK fusion.

Abstract