Dual-action depot formulation of hyaluronic acid/poloxamer in-situ gel enclosing lavender oil-based syringic acid nanoemulsion for enhanced intra-articular treatment of osteoarthritis

Key Points

• The research aims to evaluate a new formulation combining hyaluronic acid and lavender oil for treating osteoarthritis.
• Developed a dual-action depot formulation using HA, poloxamer, and lavender oil.
• Enclosed syringic acid nanoemulsion within the in-situ gel.
• Assessed therapeutic efficacy for intra-articular applications.
• The nanoemulsion displayed enhanced sustained therapeutic effects.
• Indicated potential for improved intra-articular delivery and treatment of osteoarthritis.

Abstract