Advances in cellular therapy for cancer: vector design and genome editing

Key Points

• This work aims to summarize recent advances in cellular therapies for cancer, focusing on vector design and genome editing.
• Reviewed progress in CAR T-cell therapeutics and T-cell subset nomenclature.
• Highlighted key advances in in vivo CAR generation and genome editing technologies.
• Discussed AI-guided antibody discovery platforms for enhanced immunotherapy.
• Noteworthy commercial expansion of CAR T-cell therapies despite manufacturing cost challenges.
• Transitioned to function- and state-based definitions in T-cell nomenclature for better CAR T-cell characterization.
• Introduction of innovative genome engineering techniques improving cellular therapy efficacy.

Abstract