Association Between Different Glucocorticoids and Mortality in ICU Patients With Sepsis-related Acute Respiratory Distress Syndrome: A Retrospective cohort study from MIMIC-IV Database

Key Points

• The study aims to evaluate the relationship between different glucocorticoids and mortality rates in ICU patients suffering from sepsis-related acute respiratory distress syndrome (ARDS).
• Analyzed data from the MIMIC-IV database
• Included patients diagnosed with sepsis-associated ARDS
• Compared mortality across different glucocorticoids and dosing regimens
• Methylprednisolone and dexamethasone were linked to lower mortality rates compared to hydrocortisone.
• High-dose glucocorticoid therapy was associated with increased mortality.
• Selection of glucocorticoid type and dosage significantly impacted patient outcomes.

Abstract