Association of Gastrointestinal Symptoms With Severity and Progression of Cognitive Impairment in Parkinson’s Disease: A Systematic Review and Meta‐Analysis

Key Points

• To explore the relationship between gastrointestinal symptoms, particularly constipation, and cognitive impairment in Parkinson's disease.
• Conducted a systematic review and meta-analysis
• Focused on studies reporting GI symptoms in Parkinson’s disease patients
• Performed subgroup analysis on prospective studies to assess correlations over time
• Constipation was frequently reported among patients with PD dementia
• Worsening constipation was correlated with increased cognitive impairment over a 5-year period
• Findings suggest monitoring GI symptoms may be important for PD management

Abstract