Predictive Potential of Plasma Acute Phase‐ and Adhesion‐Related Proteins and Progranulin for Intra‐Amniotic Infection/Inflammation and Spontaneous Preterm Birth in Women With Preterm Labor

Key Points

• This research aims to identify plasma biomarkers that can predict intra-amniotic infection and spontaneous preterm birth in women experiencing preterm labor.
• Evaluated plasma levels of SAA1, RBP4, E-selectin, and progranulin in women with preterm labor.
• Compared these biomarkers with ultrasound findings and traditional inflammatory blood markers.
• Analyzed the predictive potential for diagnosing intra-amniotic infection and imminent spontaneous preterm birth.
• Identified SAA1, RBP4, E-selectin, and progranulin as potential biomarkers for intra-amniotic infection.
• Combination of these biomarkers with ultrasonic and blood marker data significantly improved diagnostic accuracy for spontaneous preterm birth.

Abstract