A one pot, two steps synthesis of unsaturated esters between aryl carboxylic acids and α, β-dibromo esters is developed. This tandem reaction underwent mild conditions with a broad range of substrates scope (up to 28 examples) in moderate to excellent yields (up to 92% yield). The reaction can be easily scaled up and temperature acts as a decisive switch to control the reaction pathway.
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Miaoxiu Li
Xinyan Song
Shijie Gao
Synthesis
Shandong University of Traditional Chinese Medicine
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Li et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d896a46c1944d70ce08348 — DOI: https://doi.org/10.1055/a-2851-3784