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Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome | Synapse

April 10, 2026Open Access

Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome

Key Points

To examine how inhibiting nonsense-mediated mRNA decay affects the cancer immunopeptidome.
Collected and processed datasets from various experimental assays.
Included original western blot images for protein identification.
Used confocal microscopy to visualize cellular structures and processes.
Provided a comprehensive dataset showing alterations in the immunopeptidome.
Demonstrated changes in peptide presentation associated with mRNA decay pathways.

Abstract

This repository contains all processed datasets used to generate the figures in the associated manuscript (Vendramin et al., Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome, Immunity (2026), https://doi.org/10.1016/j.immuni.2026.02.005), including all original western blot images and raw confocal microscopy images.

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Authors

R

Roberto Vendramin

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Institutions

Cancer Institute (WIA)

The Francis Crick Institute

CRUK Lung Cancer Centre of Excellence

References and Citations

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Cite this study

Roberto Vendramin (Wed,) studied this question.

www.synapsesocial.com/papers/69d896a46c1944d70ce08387 — DOI: https://doi.org/10.5281/zenodo.10599407