December 1, 2022Open Access

Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages

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Abstract

Our findings revealed that CSF1R is a novel identified dependence receptor silenced in CRC. The silence abalienates its ligands to stimulate CSF1R expressed on M2 TAMs, which is an appealing therapeutic target for M2 TAM depletion and CRC treatment.

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Authors

Mingxuan Zhu

Liangliang Bai

Xiaoxia Liu

Journals

SHILAP Revista de lepidopterología

Journal for ImmunoTherapy of Cancer

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Institutions

Chinese Academy of Sciences

Sun Yat-sen University

Key Laboratory of Guangdong Province

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Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

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