The rise of spatial TCR profiling: Emerging technologies and open challenges

Puntos clave

• To explore the advancements in spatial TCR profiling and its role in understanding T cell behavior in tumors.
• Review of emerging technologies related to spatial TCR profiling.
• Analysis of the coordination of clonal identity and T cell states in the tumor microenvironment.
• High-definition spatial profiling provides detailed insights into T cell interactions within tumors.
• It highlights the complex relationship between T cell identity and their functional states.

Resumen