Formulation and evaluation of a polyherbal cream-gel based on medicinal leaf extracts for skin health applications

Topical formulations have been widely used for the treatment of dermatological conditions. This study aims to develop and evaluate a polyherbal cream gel formulation for topical application using leaf extracts of Calendula officinalis, Hibiscus rosa-sinensis, Bryophyllum pinnatum, and Rosa spp. The formulation was designed to integrate the benefits of cream and hydrogel systems to improve skin hydration, lubricity, and therapeutic efficacy. The cream gel was formulated using Carbopol 940 as a gelling agent with suitable excipients such as glycerine and propylene glycol to improve wetting and penetration. The developed formulation was evaluated for important physicochemical parameters, including texture, smoothness, pH, viscosity, and spreadability. The formulation showed a semi-solid consistency with smooth texture, good uniformity, and viscosity in the range of 500-1000 cps, indicating reasonable rheological behaviour. The diffusion capacity was found to be 11.33 g cm/sec, indicating ease of application, while the pH of 6.56 was within the acceptable range for a topical preparation. Biological evaluation showed significant antioxidant activity and remarkable antimicrobial activity against Staphylococcus aureus. The formulation also showed excellent moisturizing properties due to the presence of humectants and hydrophilic polymers. Stability studies confirmed that the formulation remained stable with no changes in physical properties, and irritation testing indicated that it was safe and non-irritating for topical use. Overall, the developed polyherb cream gel demonstrated promising physicochemical and biological properties, indicating its potential application in wound healing, topical drug delivery, and skin care as a natural alternative to synthetic formulations.