Effectiveness of adding esketamine to dexmedetomidine for sedation and analgesia during radiofrequency ablation and saphenous vein stripping: a randomized controlled trial

Key Points

• To evaluate the effectiveness of low-dose esketamine added to dexmedetomidine for sedation and analgesia during local anesthesia procedures.
• Randomized controlled trial design
• Comparison between two groups: esketamine and dexmedetomidine (group DE) vs. dexmedetomidine and fentanyl (group DF)
• Assessment of analgesia and sedation quality during radiofrequency ablation of the great saphenous vein
• Group DE provided better cardiovascular stability compared to group DF
• Both groups effectively achieved sedation and analgesia
• Combination of esketamine and dexmedetomidine is a promising regimen for local anesthesia surgeries

Abstract