Polydopamine-Coated Triamcinolone Acetonide Acetate Nanocrystals: Prevention of Postoperative Peritoneal Adhesion by Combining Anti-inflammation, Oxidative Stress Scavenging and Cytokine Adsorption

Key Points

• This research aims to evaluate a novel method to prevent postoperative abdominal adhesion using polydopamine-coated nanocrystals.
• Developed polydopamine-coated triamcinolone acetonide acetate nanocrystals
• Tested on a mouse model of postoperative abdominal adhesion
• Analyzed anti-inflammatory effects, oxidative stress scavenging, and cytokine adsorption
• Significantly reduced formation of abdominal adhesions
• Showed improved regulation of inflammation and oxidative stress
• Supported by histological and biochemical analyses

Abstract