HScore as a diagnostic tool in ERBB2 equivocal (immunohistochemistry 2+) breast cancer.

Key Points

• The research evaluates HScore's effectiveness as a diagnostic tool for ERBB2 equivocal breast cancer.
• Assessed predictive accuracy of HScore in breast cancer samples classified as ERBB2 equivocal (IHC 2+)
• Compared HScore results with fluorescence in situ hybridization (FISH) as the gold standard
• HScore showed moderate predictive accuracy for ERBB2 status
• Lacked adequate reliability to replace FISH as the gold standard for diagnosis

Abstract