Post-transcriptional activation of TGF-β signaling via SMAD mRNA stabilization by EIF4A3 promotes EMT and metastasis in gastric cancer

Key Points

• The research aims to explore the role of EIF4A3 in regulating TGF-β/SMAD signaling and its effect on gastric cancer metastasis.
• Identified EIF4A3's role as a regulator in the TGF-β/SMAD pathway
• Assessed its impact on epithelial-mesenchymal transition (EMT)
• Analyzed the feedback loop mechanism between EIF4A3 and TGF-β/SMAD signaling
• EIF4A3 stabilizes SMAD mRNA, enhancing TGF-β signaling activity
• The interaction facilitates EMT, contributing to increased metastatic potential in gastric cancer
• EIF4A3 is proposed as a candidate for future diagnostics and therapeutic strategies.

Abstract