Statistical analysis of potential shifts in loxoprofen sensing induced by magnetohydrodynamic effects

This study focuses on the electrochemical detection of loxoprofen, a non-steroidal anti-inflammatory drug (NSAID), and evaluates the influence of an external magnetic field on the measurement response, with particular attention to static conditions, namely the open-circuit potential.When an external magnetic field of 0.5 T was applied, the current response associated with the oxidation of loxoprofen was significantly enhanced compared with that obtained without a magnetic field.Moreover, open-circuit potential measurements under equilibrium conditions, without applying an external current, revealed a statistically significant difference in the measured potential depending on the presence or absence of the magnetic field (p < 0.05).These results indicate that the external magnetic field affects the physicochemical environment near the electrode even under current-free conditions.The observed effects are attributed to microscopic convection induced by magnetohydrodynamic effects in the electrolyte, which enhances mass transport under diffusion-controlled conditions and alters the concentration distribution of reactants and products at the electrode interface, leading to modulation of the mixed potential.This simple approach, requiring only the application of an external magnetic field, offers a promising strategy for sensitive and non-invasive electrochemical sensing in drug analysis and biosensing.