Topoisomerase 1-DNA complexes are preferentially recognised by a subset of anti-topoisomerase 1 autoantibodies and their corresponding B cell receptors in systemic sclerosis

Key Points

• This research examines how certain autoantibodies recognize topoisomerase 1 when it binds to DNA, exploring variations in the immune response among individuals with systemic sclerosis.
• Analyzed autoantibody responses to topoisomerase 1 in systemic sclerosis samples.
• Investigated B cell receptor interactions with topoisomerase 1-DNA complexes.
• Assessed the heterogeneity of the antibody response in relation to disease severity.
• Identified a specific subset of autoantibodies that preferentially recognize topoisomerase 1-DNA complexes.
• Highlighted a diverse B cell response linked to the presence of topoisomerase 1 in systemic sclerosis patients.
• Suggested that this variation may influence the progression and severity of the disease.

Abstract