Synthesis and Anticancer Activity of Novel 1,2,3-Triazole-Linked Thiazole Derivatives

A series of novel 2-aminothiazole–1,2,3-triazole hybrid compounds were synthesized using a click chemistry strategy, specifically by coupling substituted N-(4-aryl-1,3-thiazol-2-yl)-2-azidoacetamides with terminal alkynes. The structures of the resulting compounds were confirmed through spectroscopic methods, including 1H and 13C NMR, mass spectrometry, infrared spectroscopy, and elemental analysis. The anticancer efficacy of compounds 5a–5j was assessed against a panel of 60 human cancer cell lines, following the NIH screening protocol. Among the tested compounds, 5a, 5b, 5f, 5g, 5h, and 5j exhibited significant inhibitory activity.