Deep brain stimulation or best medical treatment for Parkinson’s disease patients: 36-month longitudinal neuropsychological and motor assessment — a prospective case-control study

Key Points

• This research examines the effects of deep brain stimulation compared to best medical treatment on cognitive and motor functions in Parkinson's disease patients.
• Prospective case-control design
• Longitudinal assessment over 36 months
• Comparison of cognitive and motor outcomes between DBS STN and medical treatment groups
• Use of UPDRS III to measure motor severity
• DBS STN did not show significant improvements in cognitive performance compared to medical treatment
• Active DBS STN improved motor symptoms but could not reduce worsening of OFF-motor severity
• Motor symptom progression was similar between both treatment groups over the study period

Abstract