Associations of Monocyte Glucocerebrosidase with Cognition and Cholinergic Innervation in GBA1 Parkinson's Disease

Key Points

• The research aims to investigate the relationship between monocyte glucocerebrosidase activity and cognitive decline in early-stage Parkinson's Disease.
• Analyzed monocytic GCase activity in relation to cognition and cholinergic innervation in patients with Parkinson's Disease.
• Evaluated peripheral measurements and their correlation with central cholinergic dysfunction.
• Assessed cognitive decline using established cognitive assessment tools.
• Monocytic GCase activity did not correlate with cognitive decline in early-stage Parkinson's Disease.
• No significant link was found between GCase activity and regional cholinergic denervation.
• Peripheral measurements are not indicative of central cholinergic dysfunction.

Abstract