What question did this study set out to answer?

This research aims to evaluate the impact of mosaic embryos on reproductive outcomes and the relevance of current mosaicism reporting.

April 15, 2026Open Access

Reproductive outcomes of mosaic embryo transfers – rethinking the clinical relevance of contemporary mosaicism reporting in preimplantation genetic testing for aneuploidy

Key Points

This research aims to evaluate the impact of mosaic embryos on reproductive outcomes and the relevance of current mosaicism reporting.
Analyzed outcomes of mosaic embryo transfers
Focused on the identification of constitutional aneuploidy
Reassessed clinical protocols regarding mosaicism reporting
Highlights that mosaicism may not be clinically actionable
Revealed that identifying constitutional aneuploidy is crucial for reproductive success
Challenges existing views on the significance of mosaic embryos in fertility treatments

Abstract

These findings shift the conceptual framework away from mosaicism as a clinically actionable diagnosis and toward a model in which accurate identification of constitutional aneuploidy is the principal determinant of reproductive outcome.

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Authors

Christian S. Ottolini

Silvia Caroselli

Antonio Capalbo

Journals

Current Opinion in Obstetrics & Gynecology

Actions

Institutions

University College London

Sapienza University of Rome

University of Chieti-Pescara

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Reproductive outcomes of mosaic embryo transfers – rethinking the clinical relevance of contemporary mosaicism reporting in preimplantation genetic testing for aneuploidy

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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