Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial

Key Points

• To evaluate the effects of mepolizumab on airway physiology outcomes following functional endoscopic sinus surgery in adults with CRSwNP.
• Conducted a randomised controlled trial.
• Administered mepolizumab to patients undergoing functional endoscopic sinus surgery.
• Assessed airway hyperresponsiveness through bronchial challenges.
• Airway hyperresponsiveness significantly improved after treatment with mepolizumab.
• The improvement was particularly evident during indirect bronchial challenges.

Abstract