Circulating tumor DNA dynamics in patients with liver-limited metastatic colorectal cancer resected after first-line systemic treatment

Key Points

• The research aims to evaluate how ctDNA changes after chemotherapy can predict patient outcomes in liver-limited metastatic colorectal cancer.
• Utilized a tumor-naive MRD assay to measure ctDNA levels post-chemotherapy.
• Analyzed ctDNA dynamics prior to surgery in patients.
• Investigated the relationship between ctDNA levels and relapse-free survival.
• Detected a significant decrease in ctDNA levels after chemotherapy.
• Found that pre-surgery ctDNA levels are prognostic for relapse-free survival.
• Indicated potential for improving personalized treatment strategies based on ctDNA assessment.

Abstract