The end of ’leaky gut’: pathway-specific mechanistic approaches to barrier restoration

Key Points

• This research aims to redefine intestinal barrier biology through specific mechanistic pathways for therapeutic approaches.
• Developed a pathway-resolved framework for intestinal barrier biology
• Identified specific mechanisms impacting intestinal barrier function
• Explored the potential of new therapeutic approaches.
• Introduced independent and complementary strategies to existing immune-targeted therapies
• Highlighted the importance of specific pathways in restoring intestinal barrier integrity.

Abstract