Subarachnoid Hemorrhage Induces mPFC CRF Neuronal Dysfunction Leading to Anxiety and Depression in Male Mice

Key Points

• This research examines how subarachnoid hemorrhage (SAH) affects mPFC CRF neurons, contributing to anxiety and depression.
• Investigated the impact of SAH on mPFC CRF neuronal activity in male mice.
• Analyzed the modulation of mPFC neuron activity by basolateral amygdala inputs.
• Assessed the downregulation of SYT9 as a mechanism of neuronal impairment.
• Identified dysfunction of mPFC CRF neurons as a key feature after SAH.
• Found that the modulation by basolateral amygdala is significant for mPFC neuron activity.
• Demonstrated that SYT9 downregulation contributes to the impairment of mPFC CRF neurons.

Abstract