Chronic Thromboembolic Pulmonary Disease Phenotypes Using Upright Invasive Cardiopulmonary Exercise Testing

Key Points

• This research aims to improve the diagnostic understanding of chronic thromboembolic pulmonary disease through advanced exercise testing.
• Conducted upright invasive cardiopulmonary exercise testing (iCPET) on patients with chronic thromboembolic pulmonary disease.
• Defined ventilatory inefficiency specifically to assess exercise response.
• Focused on patient phenotypes experiencing unexplained dyspnea despite normal resting pulmonary pressures.
• Ventilatory inefficiency was prevalent among patients tested, particularly in those with preload insufficiency.
• Identification of such patients was enhanced by the defined criteria during exercise testing.
• Misclassification of patients was observed without the use of specific exercise metrics.

Abstract