What question did this study set out to answer?

This study examines how ethanol exposure influences neurexin expression and synapse stability in neuroblastoma cells.

April 15, 2026Open Access

Ethanol Alters the Neurexin Landscape in Human Neuroblastoma Cells

Key Points

This study examines how ethanol exposure influences neurexin expression and synapse stability in neuroblastoma cells.
Exposure of human neuroblastoma cells to ethanol
Analysis of NRXN expression levels
Assessment of isoform and splice site changes
Evaluation of transcriptional and proteomic alterations
Ethanol exposure alters NRXN expression in a specific isoform- and splice site-dependent manner
Prominent effects observed in NRXN3 and the SS4 splice site
Disruption of NRXN3β-NLGN2 interactions noted
Impairment of inhibitory synapse stability indicated

Abstract

Physiologically relevant ethanol exposure alters NRXN expression in an isoform-, splice site-, and differentiation-dependent manner, prominently affecting NRXN3 and the SS4 site. These coordinated transcriptional and proteomic changes suggest that ethanol perturbs NRXN3β-NLGN2 interactions and inhibitory synapse stability, revealing a molecular pathway where alcohol may compromise cortical network excitatory-inhibitory balance.

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Discussion

Authors

Clara C. Lowe

Kip D. Zimmerman

Rita Cervera‐Juanes

Journals

Alcohol Clinical and Experimental Research

Actions

Institutions

Wake Forest University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Ethanol Alters the Neurexin Landscape in Human Neuroblastoma Cells

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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