An MRI of a 25-year-old adult male patient after an episode of acute pancreatitis revealed a multiloculated pancreatic head cyst with a mural nodule. Endoscopic biopsy and molecular analysis showed wild-type KRAS, GNAS and TP53. Due to diagnostic uncertainty, a surgical resection was performed and revealed acinar cystic transformation (ACT), a rare benign lesion. ACT should be considered in differential diagnosis of pancreatic cysts, especially in young patients.
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Christos Longros
Dietrich Alexander Ruess
Clinical Journal of Gastroenterology
Heidelberg University
German Cancer Research Center
University Medical Center Freiburg
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Longros et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69df2c88e4eeef8a2a6b1bb7 — DOI: https://doi.org/10.1007/s12328-026-02318-z