peri-Selective C−H Activation-Initiated Spiroannulation Leading to Spiro Polycyclic Compounds with Unique Photo-Physical Property and Strong Anticancer Activity

Key Points

• The aim is to develop a peri-selective C−H activation method for creating spirocyclic compounds with unique properties.
• Developed a peri-selective C−H activation strategy.
• Performed reactions to construct spirocyclic skeletons efficiently.
• Synthesized benzo[de]isoquinoline derivatives as targets.
• Successfully created spirocyclic compounds with distinct photophysical properties.
• Identified strong anticancer activity in synthesized compounds.

Abstract