The predominance of effectiveness issues over traditional safety concerns distinguishes aesthetic BoNT-A pharmacovigilance from typical pharmaceutical surveillance. Geographic concentration of reporting in the United States despite global market distribution indicates systematic underreporting internationally. These findings suggest current pharmacovigilance systems inadequately capture aesthetic medicine adverse events, with direct implications for patient safety and regulatory oversight.
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Alexander Zargaran
David Zargaran
Ali Pirayesh
Journal of Cosmetic Dermatology
University College London
The Royal Free Hospital
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Zargaran et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69df2cf7e4eeef8a2a6b20af — DOI: https://doi.org/10.1111/jocd.70771