What question did this study set out to answer?

To evaluate the impact of donor selection on overall survival in HLA-homozygous transplant recipients.

April 16, 2026Open Access

Donor selection for patients with HLA-homozygous haplotypes in allogeneic hematopoietic stem cell transplantation

Key Points

To evaluate the impact of donor selection on overall survival in HLA-homozygous transplant recipients.
Registry analysis of first allogeneic transplants
Comparison of related vs. cord blood donor outcomes
Focus on survival rates in different donor scenarios
Overall survival rates did not significantly differ between related donor hetero-to-homo and cord blood hetero-to-homo transplantation.
Cord blood homo-to-homo transplantation was linked to worse survival outcomes.

Abstract

Registry analysis of first allogeneic transplant in HLA-homozygous recipients.Overall survival did not significantly differ with related donor hetero-to-homo or cord blood hetero-to-homo transplantation.Cord blood homo-to-homo transplantation was associated with inferior survival in the primary analysis.

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Discussion

Authors

Noriyoshi Yoshinaga

Makoto Iwasaki

Koji Kato

Journals

Annals of Hematology

Actions

Institutions

Kyoto University

Kyushu University

Keio University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Donor selection for patients with HLA-homozygous haplotypes in allogeneic hematopoietic stem cell transplantation

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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