Abstract Background 95% CI: 0.44-0.79) and fracture (HR: 0.77; 95% CI: 0.63-0.95). Using elastic net regression, we identified 51 metabolites characterizing the weekend warrior pattern and 62 metabolites representing regular physical activity. Each standard deviation (SD) increase in the weekend warrior-related metabolomic signature corresponded to a 27% lower risk of osteoporosis (HR: 0.73; 95% CI: 0.62-0.85) and a 12% lower risk of fracture (HR: 0.88; 95% CI: 0.79-0.99). These associations were not significantly modified by genetic susceptibility to osteoporosis (P = 0.429) or fracture (P = 0.221). Conclusions The weekend warrior pattern was associated with lower risks of osteoporosis and fracture. We further identified distinct metabolomic signature characterizing this pattern, providing potential mechanistic insights into its protective effects.
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Huang et al. (Sat,) studied this question.
www.synapsesocial.com/papers/69e07cfa2f7e8953b7cbe10d — DOI: https://doi.org/10.1093/jbmr/zjag067
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
Huan Huang
Jiong Liu
Peixuan Li
Journal of Bone and Mineral Research
Harvard University
Tulane University
Shenzhen University
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