Amine dehydrogenases: a versatile class of enzymes in the asymmetric synthesis of chiral amines and amino alcohols

Key Points

• The aim is to explore the role of amine dehydrogenases in synthesizing chiral amines and amino alcohols.
• Investigated the catalytic activity of engineered amine dehydrogenases
• Examined the reductive amination process with various carbonyl compounds
• Evaluated outcomes using different amino donors
• Demonstrated successful synthesis of chiral amines with high enantiomeric excess
• Showed that engineered enzymes improve reaction efficiency
• Revealed potential for broad application in organic synthesis

Abstract