Successful management of multiple intra‐abdominal granulomas caused by Scedosporium apiospermum in a Border Collie using a combination of surgery and voriconazole

Abstract A 6‐year‐old, female, neutered Border Collie was presented for investigation of chronic vomiting and weight loss. Abdominal ultrasonography and computed tomography identified a jejunal mass with mesenteric lymphadenopathy. Exploratory coeliotomy with enterectomy, splenectomy and partial pancreatectomy was performed. Histopathology demonstrated transmural pyogranulomatous enteritis with intralesional fungal hyphae. Fungal species identification was not possible. Eighteen months later, the dog re‐presented with lower urinary tract clinical signs. Abdominal ultrasound revealed multiple intra‐abdominal masses. Surgical excision of accessible lesions was performed. One large diaphragmatic mass was considered unresectable. Histopathology confirmed fungal granulomatosis, and fungal culture with polymerase chain reaction identified Scedosporium apiospermum . Oral voriconazole therapy was administered. Six months postoperatively, the patient showed marked clinical improvement, with full imaging and clinicopathological resolution confirmed at 7 and 9 months. This is the first documented case of S. apiospermum ‐associated peritoneal fungal granulomatosis in the UK, successfully treated with a combination of surgery and antifungal therapy.