Metabolomics of Right Ventricular Function in Pulmonary Hypertension

Key Points

• To explore the relationship between metabolites and right ventricular (RV) function in pulmonary hypertension (PH).
• Identified metabolites and metabolic pathways linked to RV systolic function.
• Analyzed differences in metabolite associations by PH groups and pulmonary vascular resistance categories.
• Investigated the impact of androgenic steroids on RV function across sexes.
• Novel associations were found between metabolites, particularly vitamin A and glutathione, and RV function.
• Differences in metabolite associations were noted based on PH status and resistance.
• Stronger associations for androgenic steroids with RV systolic function were observed in females than in males.

Abstract