Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248

Key Points

• To evaluate the effects of combined MEK and AKT inhibition on melanoma stem cell apoptosis and tumor growth.
• Combined MEK and AKT inhibition in melanoma cell lines
• Assessment of apoptosis rates in stem cells
• Evaluation of tumor growth metrics in NRAS-driven models
• Combined inhibition led to significant increase in apoptosis rates of melanoma stem cells
• Blocked tumor growth in NRAS-positive models
• Demonstrated synergistic effects when both pathways were targeted

Abstract