What question did this study set out to answer?

This research aims to explore new synthetic pathways for creating chiral imidazolidines.

April 18, 2026Open Access

Synthesis of (S)-4-Benzyl-3-butyl-1-(2-cycloheptylethyl)imidazolidine

Key Points

This research aims to explore new synthetic pathways for creating chiral imidazolidines.
LiAlH4 reduction of specific tert-butyl carbamate to produce imidazolidine
Treatment with lithium diisopropylamide to achieve β-elimination
Full characterization of products synthesized
Successfully synthesized imidazolidine and cinnamamide as products
Demonstrated viability of reductive cyclization for creating chiral imidazolidines

Abstract

LiAlH4 reduction of tert-butyl (S)-butyl(1-((2-cycloheptylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (1) gave imidazolidine 2, while treatment with lithium diisopropylamide furnished the β-elimination product, cinnamamide 3. Both products were fully characterized. Reductive cyclization of N-alkylated-N-Boc-protected amino acid amides with LiAlH4 may be a viable synthetic method for trisubstituted chiral imidazolidines.

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Authors

Matevž Schweiger

Luka Ciber

Nejc Petek

Journals

Molbank

Actions

Institutions

University of Ljubljana

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Building similarity graph...

Analyzing shared references across papers

Synthesis of (S)-4-Benzyl-3-butyl-1-(2-cycloheptylethyl)imidazolidine

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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