This review highlights that cardiometabolic disorders and genetic modulators share common pathophysiological mechanisms with aging, offering potential targets to delay cardiovascular aging.
Cardiovascular aging and longevity
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dyslipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goal of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations.
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P Pietri
Christodoulos Stefanadis
Journal of the American College of Cardiology
National and Kapodistrian University of Athens
Athens State University
Athens Medical Center
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Pietri et al. (Fri,) conducted a review in Cardiovascular aging and longevity. This review highlights that cardiometabolic disorders and genetic modulators share common pathophysiological mechanisms with aging, offering potential targets to delay cardiovascular aging.
www.synapsesocial.com/papers/69e69844c715c26d55d593ea — DOI: https://doi.org/10.1016/j.jacc.2020.11.023