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April 25, 2026Open Access

Early-Onset Metastatic Colorectal Adenocarcinoma Incidence and Survival Among Patients Younger Than 50 Years

Key Points

To assess the incidence and survival rates of early-onset metastatic colorectal adenocarcinoma (EO mADC) in patients younger than 50 years.
Cohort study design
Analysis of incidence based on metastatic sites, focusing on peritoneal involvement
Evaluation of survival improvements over time
Incidence of EO mADC increased mainly among patients with multiple metastatic sites and peritoneal involvement.
Net survival improved over time, except for those with peritoneal involvement.
Intensive treatment is suggested for young adults with EO mADC when peritoneal involvement occurs.

Abstract

In this cohort study, the incidence of EO mADC increased mainly among patients with multiple metastatic sites and those with peritoneum rather than liver or lung involvement. Net survival improved over time except for peritoneal involvement. These results suggest that intensive treatment is needed for young adults with EO mADC when the peritoneum is involved.

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Discussion

Authors

Valérie Jooste

François Ghiringhelli

Jean-Baptiste Nousbaum

Journals

JAMA Network Open

Actions

Institutions

Inserm

Université Paris Cité

Sorbonne Paris Cité

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Early-Onset Metastatic Colorectal Adenocarcinoma Incidence and Survival Among Patients Younger Than 50 Years

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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