T cell counts, as well as, T cell sEV RNA cargoes (Cd3, Cd8, Ifng, Tcrb, and microRNA (Mir)21a) were significantly upregulated in mice receiving allogeneic compared to syngeneic lungs at the postoperative day 7 time point. Second, translating these findings to clinical lung transplantation, we analyzed circulating T cell sEV RNA cargoes with time-matched surveillance transbronchial allograft biopsies in 20 patients. In eight patients with >A1 ACR, eight candidate RNA biomarkers (CD8, TCR, IFNG, HLA-DRA, CD38, MIR21, MIRLET7I, MIR101) were significantly upregulated compared to 12 patients without ACR. Collectively, these findings support further investigation of T cell sEVs as a novel biomarker for ACR diagnosis in lung transplantation.
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Laxminarayana Korutla
Katsutaka Mineura
Nicole DeMarais
Yale University
Washington University in St. Louis
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Korutla et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69f6e5cf8071d4f1bdfc6628 — DOI: https://doi.org/10.1016/j.ajt.2026.04.021