Pediatric Rotavirus A Infection Among 337,019 Participants Within Asia: A Pan-Asian Systematic Review and Meta-Analysis.

Background: Rotavirus A remains a leading cause of acute gastroenteritis in children under 5 years of age across Asia, despite expanding vaccination programs. This study systematically synthesizes available evidence on rotavirus A detection among pediatric populations in Asian countries. Methods: statistic. Results: < 0.001), reflecting wide variation in study populations, diagnostic methods, and healthcare settings. Higher test positivity rates were reported in studies from Saudi Arabia (49.3%), Iran (35.2%), Malaysia (33.0%), and India (29.4%), whereas lower proportions were observed in China (13.0%) and Pakistan (18.8%). Diagnostic modality and study design significantly influenced detection rates, with ELISA-based and cross-sectional studies reporting higher positivity. Conclusion: Approximately one-quarter of children tested for rotavirus A across Asia were laboratory-positive, although estimates varied markedly across settings and thus stress the need for a routine vaccination program.