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Advancing targeted protein degradation: pLIRTAC’s role in glioma and CAR-T cell therapy | Synapse

May 6, 2026Open Access

Advancing targeted protein degradation: pLIRTAC’s role in glioma and CAR-T cell therapy

Key Points

To investigate the role of pLIRTAC in advancing targeted protein degradation (TPD) in glioma and CAR-T cell therapy.
Analyzed the effects of pLIRTAC on protein degradation in glioma cells.
Assessed the therapeutic implications of TPD technology in CAR-T cell therapy.
pLIRTAC effectively controls abnormal proteins in glioma cells.
Study indicates potential for expanding TPD applications in immune therapies like CAR-T.

Abstract

, providing a robust and effective tool for the control of endogenous abnormal proteins in cells, and can potentially further expand the therapeutic application of TPD technology.

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Authors

K

Kunjian Lei

Y

Yishuang Li

Z

Zhihong Zhou

Journals

Autophagy

Actions

Institutions

Jiangnan University

Nanchang University

Second Affiliated Hospital of Nanchang University

References and Citations

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Cite this study

Lei et al. (Mon,) studied this question.

www.synapsesocial.com/papers/69fa8ef304f884e66b53153d — DOI: https://doi.org/10.1080/15548627.2026.2668653