The Expanding Landscape of ADP-Ribosylation: Protein, DNA, RNA, and Mitochondrial Regulation

Key Points

• This research aims to explore the roles of ADP-ribosylation in regulating DNA and post-translational modifications.
• Analysis of ADP-ribosylation types in mammalian and bacterial cells
• Discussion of terminal and nucleobase-linked ADP-ribosylation
• Examination of NAD capping and its interactions
• Identified multiple types of ADP-ribosylation in DNA and RNA
• Explored the interplay between ADP-ribosylation and protein modifications
• Discussed physiological implications of these modifications

Abstract