Studies on the Lewis acid catalyzed synthesis of isoxazolidin-3-ones

Key Points

• To investigate a Lewis acid catalyzed method for synthesizing isoxazolidin-3-ones using a sustained-release substrate strategy.
• Employing Lewis acid catalysts to facilitate the reaction under mild conditions.
• Implementing a sustained-release strategy to prevent catalyst poisoning during the synthesis process.
• Utilizing chiral epoxy substrates to assess enantiomeric purity of the products.
• Synthesis of a wide array of substituted isoxazolidin-3-ones was achieved efficiently.
• Utilization of inexpensive starting materials made the process cost-effective.
• High retention of enantiomeric purity was obtained when chiral substrates were used.

Abstract