Immune checkpoint blockade targets macrophage PD-1 to exacerbate metabolic dysfunction

Key Points

• To investigate the role of macrophage PD-1 in metabolic dysfunction associated with immune checkpoint inhibitor therapies.
• Evaluated the effects of anti-PD-1 treatment on metabolic functions in macrophages.
• Assessed the influence of macrophage PD-1 blockade on endoplasmic reticulum stress and inflammatory responses.
• Analyzed metabolic outcomes such as energy expenditure and adipose tissue thermogenesis.
• Macrophage PD-1 blockade led to impaired thermogenesis and reduced energy expenditure.
• The blockade exacerbated systemic metabolic dysfunction as indicated by increased endoplasmic reticulum stress.
• P=0.01 indicating significance in metabolic disruption following PD-1 targeting.

Abstract