What question did this study set out to answer?

To explore the relationship between SOD2 genetic variants and hepatotoxicity in pediatric leukemia across different ethnic groups.

May 7, 2026Open Access

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Key Points

To explore the relationship between SOD2 genetic variants and hepatotoxicity in pediatric leukemia across different ethnic groups.
Analyzed genetic data from children with Acute Lymphoblastic Leukemia
Compared hepatotoxicity rates between Hispanic and non-Hispanic children
Calculated adjusted odds ratios for hepatotoxicity linked to SOD2 rs4880 variant.
Hispanic children showed increased odds of hepatotoxicity (aOR = 1.81) associated with SOD2 rs4880 variant
Non-Hispanic children demonstrated decreased odds of hepatotoxicity (aOR = 0.55)
Evidence of genetic variations impacting hepatotoxic risk across ethnicities.

Abstract

), but decreased odds in non-Hispanic children (aOR = 0.55, 95% CI: 0.32-0.94, p = 0.03). These findings highlight potential ethnicity-specific differences in genetic contributors to TAH risk and highlight the need for mechanistic studies.

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Authors

Emily J. Mason

John P. Woodhouse

Joanna S. Yi

Journals

Pediatric Blood & Cancer

Actions

Institutions

University of California, Los Angeles

University of California, San Francisco

Emory University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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