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May 7, 2026

Pharmacokinetic Profiles of Enrofloxacin and Its Metabolite Ciprofloxacin Administered by Different Doses in Calves

Key Points

This research aims to assess the pharmacokinetic profiles of enrofloxacin and its metabolite ciprofloxacin in calves under different dosing conditions.
Administered enrofloxacin and ciprofloxacin at varying doses to calves.
Monitored pharmacokinetic profiles for dose-dependent changes.
Evaluated the conversion ratio of enrofloxacin to ciprofloxacin.
Ciprofloxacin levels increased in a dose-dependent manner (p < 0.05).
No significant alteration in the conversion ratio of enrofloxacin to ciprofloxacin (26%-28%, p > 0.05).
Pharmacokinetics exhibited considerable variability based on dosage.

Abstract

of CIP increased in a dose-dependent manner (p 0.05). The results of the current investigation demonstrated that the pharmacokinetics of ENR and CIP in calves had considerable variability with dose. Assessing dose-dependent pharmacokinetic alterations in calves can aid in establishing the dosing regimen; however, additional research is required to confirm dose-dependent therapeutic efficacy and safety.

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Discussion

Authors

Kamil Üney

Orhan Çorum

Murat Yüksel

Journals

Journal of Veterinary Pharmacology and Therapeutics

Actions

Institutions

University of Pisa

Universidad de Murcia

Selçuk University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Pharmacokinetic Profiles of Enrofloxacin and Its Metabolite Ciprofloxacin Administered by Different Doses in Calves

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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