Amyloid PET Burden, CSF Biomarkers, and APOE Genotype in People With Iatrogenic and Sporadic Cerebral Amyloid Angiopathy

BACKGROUND AND OBJECTIVES: genotype between iCAA and sporadic CAA (sCAA). METHODS: florbetaben PET scans. CSF Aβ42, Aβ40, Aβ42/Aβ40 ratio, p-tau181, and total tau (t-tau) were measured with Lumipulse assays. Multivariable regression adjusted for age and sex examined associations with Centiloid values. RESULTS: ε4 was markedly less frequent in iCAA (4.5% vs 34.2%). DISCUSSION: Patients with iCAA exhibit higher amyloid burden and a distinct biomarker profile compared with those with sCAA, supporting a divergent-possibly exogenous-mechanism of amyloid propagation. TRIAL REGISTRATION INFORMATION: SENECA, ClinicalTrials.gov Identifier: NCT04204642 (submitted on December 19, 2019).