Involvement of interaction between TRPM2 and IKCA1 in temperature-dependent movement and IL-1β production in mouse microglia

Puntos clave

• This research aims to investigate how the interaction between TRPM2 and IKCA1 affects microglial movement and IL-1β production at different temperatures.
• Observed mouse microglia movement and IL-1β production in vitro under varying temperatures.
• Assessed the role of TRPM2 and IKCA1 interaction in these processes.
• Mouse microglia showed increased movement at physiological temperatures due to TRPM2-IKCA1 interaction.
• The interaction also enhanced IL-1β cytokine production under the same conditions.

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