What question did this study set out to answer?

This research aims to explore the role of ERα in dendritic cells and its effect on antigen cross-presentation and T cell immunity.

May 8, 2026Open Access

ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity

Puntos clave

This research aims to explore the role of ERα in dendritic cells and its effect on antigen cross-presentation and T cell immunity.
Investigated the function of ERα in dendritic cells
Analyzed phagosome integrity involved in antigen processing
Evaluated CD8+ T cell responses to ERα blockade
ERα blockade improves antigen cross-presentation in dendritic cells
Enhanced CD8+ T cell immunity observed
Identified phagosome integrity as a critical checkpoint for antigen processing

Resumen

T cells. Our work thus uncovers a non-canonical role of ERα in phagosome integrity as a checkpoint for antigen cross-presentation in DCs, and implicates ERα-targeted DC vaccines as a potential immunotherapeutic strategy.

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Authors

Yaxin Liu

Zhongfei Ma

Xuelian Li

Journals

Nature Communications

Actions

Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Nankai University

Suzhou Institute of Systems Medicine

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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